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Conditions of optimal BD 1 Protein Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Introduction
The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.
Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis.
BP000060-CYT-564: Recombinant Human Beta-defensin 1 (BD-1) Protein
Source: E. coli-derived.
Predicted molecular mass: 5 KDa.
The specific activity is determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000 ug/ml corresponding to a specific activity of 1,000-10,000 IU/mg.
Purity: > 98% by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (1 ug/ml) solution containing 20 mM PBS pH-7.4 and 130 mM sodium chloride.
Reconstitution: It is recommended to reconstitute the lyophilized Beta Defensin-1 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other BD-1 Proteins:
Recombinant Mouse BD-1 Protein
Recombinant Mouse BD-1 Protein
Recombinant Rat BD-1 Protein
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