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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal BclXL Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells.
Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity and therefore acts as a survival protein.
BP001832-PRO-641: Recombinant Human B-Cell Lymphoma Extra Large, His Tag (BclXL) Protein
Source; E. coli-derived.
Recombinant Human Bcl-XL Human is a single, non-glycosylated polypeptide chain containing amino acids 1-210. The Bcl-XL is expressed as His-Tag fusion protein and purified by proprietary chromatographic techniques.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The protein contains 10 mM Tris-HCL pH-8, 1 mM EDTA and 250 mM NaCl.
Reconstitution: Suspend BclXL in 100 ? of 0.5 M Acetic acid, over night at 4°C. Dilute 10 fold into selected buffer system. Bcl-XL has tendency to form intramolecular disulfide bond, 5 mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10 mM DTT is recommended.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other BclXL Proteins:
Recombinant Human B-Cell Lymphoma Extra Large, GST Protein
Recombinant Human B-Cell Lymphoma Extra Large Protein
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