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Background Information:
AZD4635 (HTL-1071) is an orally bioavailable, potent and selective A2A (Adenosine 2A) receptor antagonist, binding to human A2A receptor with a Ki value of 1.7 nM, and with > 30-fold selectivity over other adenosine receptors. High adenosine level in tumors, produced by stimulating A2A receptors, is immune suppressive, which prevents T-cells within the immune system from being activated thus reduces their ability to destroy cancer cells. Antagonizing A2A receptors can therefore promote the anti-cancer response of T-cells within the tumour microenvironment. AZD4635 is currently being evaluated as a monotherapy and in combination with other anti-PDL1 agents in patients with advanced solid cancers.
APIM050269: AZD4635 (HTL-1071)
CAS No.: 1321514-06-0.
Molecular Formula: C15H11ClFN5.
Molecular Weight: 315.7.
Purity: >99% by HPLC.
QC: HPLC-MS, 1H-NMR, and Quantitative Elemental Analysis.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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