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Conditions of optimal AURKB Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Aurora Kinase B (AURKB) belongs to a family of mitotic serine/threonine kinases. AURKB connects with chromosomes for the period of prophase prior to relocalizing to the spindle at anaphase. AURKB localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB controls chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. AURKB is required for kinetochore localization of BUB1 and SGOL1. AURKB expression during the G2/M phase transition is firmly coordinated with histone H3 phosphorylation, while overexpression is seen in many kinds of cancers. AURKB phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. AURKB is a component of the CPC (chromosomal passenger complex), which is a complex that acts as a key regulator of mitosis.
High level expression of AURKB is seen in the thymus, which is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. AURKB is expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
BP002488-PKA-355: Recombinant Human Aurora Kinase B (AURKB) Enzyme
Source: E. coli-derived.
A single, non-glycosylated, polypeptide chain containing 364 amino acids (1-344) and having a molecular mass of 41.4 kDa. AURKB is fused to 20 a.a. His-Tag at N-terminus.
Purity: > 90.0% as determined by SDS-PAGE.
Formulation: The AURKB solution containing 20 mM Tris-HCl buffer (pH8.0), 0.5 mM DTT, 20% glycerol, 0.1 mM EDTA, 0.1 mM EGTA, 0.1 M NaCl and 0.1 mM PMSF.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
AURKB Antibodies:
AURKB Polyclonal Antibody
AURKB Monoclonal Antibody
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