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Conditions of optimal ATPIF1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
ATPase inhibitory factor 1 (ATPIF1) attaches to the C-terminal region of a beta subunit of the F1-ATPase at low pH values and, through interference of the beta and gamma subunit interaction, ATPIF1 controls the activity of the F1 (the hydrophilic catalytic core), F0 (the membrane embedded protein channel) ATPase. ATPIF1 overexpression in a number of human carcinomas additionally reinforces its participation in oncogenesis and offers insight into the transformed metabolism of cancer cells, including the reprogramming of energy metabolism in relation to glycolysis. Endogenous F1F(o)-ATPase inhibitor curbing ATP depletion when the mitochondrial membrane potential drops below a threshold and the F1F(o)-ATP synthase begins hydrolyzing ATP to pump protons out of the mitochondrial matrix.
BP003025-PRO-1154: Recombinant Human ATPase Inhibitory Factor 1 (ATPIF1) protein
Source: E. coli-derived.
Recombinant Human ATPase Inhibitory Factor 1 (ATPIF1) protein is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Predicted molecular mass: 12.2 kDa.
Purity: > 95.0% by SDS-PAGE.
Formulation: ATPIF1 protein solution (1 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 0.2 M NaCl, 50% glycerol and 2 mM DTT.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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