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Conditions of optimal APEX1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
BP000676-ENZ-059: Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 (APEX1) Enzyme
Source: E. coli-derived.
APEX1 protein is a single, non-glycosylated, polypeptide chain containing 332 amino acids (1-318a.a.) and having a molecular mass of 36.9 kDa. It is fused to a 14 amino acid T7-tag at N-terminus.
Purity: > 90% by SDS-PAGE.
Formulation: APEX1 solution (1 mg/1 ml) containing 20 mM Trsi HCL pH-8, 2 mM DTT, 0.2 M NaCl, and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other APEX1 Enzymes:
Recombinant Human APEX1 Enzyme
APEX1 Antibodies:
APEX1 Polyclonal Antibody
APEX1 Polyclonal Antibody
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