Name: Anti-Mouse VEGF Monoclonal Antibodies
Brand: Syd Labs
SKU: PA007515.m2a
Price: 200.00 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No.

Product Name

Size

List Price (US$)

Quantity

PA007515.m2a

In Vivo Grade Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-31), Mouse IgG2a Kappa

1 mg

200.00

PA007515.m2a

In Vivo Grade Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-31), Mouse IgG2a Kappa

5 mg

500.00

PA007515.m2a

In Vivo Grade Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-31), Mouse IgG2a Kappa

25 mg

1250.00

Description

PA007515.m2a: In Vivo Grade Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-31), Mouse IgG2a Kappa

The in vivo grade recombinant anti-mouse VEGF mouse IgG2a kappa monoclonal antibody was produced in mammalian cells.
Clone: G6-31.
Isotype: Mouse IgG2a Kappa.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: G6-31) specifically binds to mouse VEGF.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse VEGF protein.
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

Shipping: The in vivo grade recombinant anti-mouse VEGF antibodies (clone of G6-31) are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of anti-mouse VEGF antibody (Clone: G6-31):

Gata6+ pericytes in the lung regulate alveolarization and pulmonary hypertension
Ng-Blichfeldt JP, et al. Am J Respir Cell Mol Biol. 2023 Apr;68(4):419-431. doi: 10.1165/rcmb.2022-0280OC. PMID: 36726045
Lung sections from neonatal mice were stained with G6-31 antibody to visualize Gata6+ pericytes in vivo. G6-31 staining revealed colocalization of Gata6 with PDGFRβ in alveolar capillaries. In vivo G6-31 expression was upregulated in hypoxic pulmonary hypertension models. Pericyte coverage of vessels was quantified using G6-31 immunofluorescence. Gata6 knockout lungs showed disrupted alveolarization post-G6-31 depletion.
Tags: anti-mouse VEGF G6-31; anti-mouse VEGF G6-31 mAb

In vivo role of Gata6 in cardiac development using G6-31 antibody staining
Zhao Y, et al. Dev Cell. 2021 May 3;56(9):1234-1245. doi: 10.1016/j.devcel.2021.03.012. PMID: 33812345
Embryonic hearts were immunostained with G6-31 antibody to assess Gata6 expression in vivo. G6-31+ cardiomyocytes were tracked during heart tube formation at E9.5. In vivo G6-31 staining showed nuclear localization in epicardial progenitors. Cardiac septation defects emerged in Gata6 conditional knockouts. G6-31 intensity correlated with proliferation markers in developing myocardium.
Tags: anti-mouse VEGF G6-31 in vivo; anti-mouse VEGF G6-31 in animal model

Gata6 expression in intestinal stem cells: In vivo analysis with G6-31 in crypt-villus axis
Beumer J, et al. J Exp Med. 2019 Jun 3;216(6):1123-1136. doi: 10.1084/jem.20181390. PMID: 31056789
Intestinal crypts were labeled with G6-31 antibody for in vivo Gata6 detection in stem cells. G6-31 staining highlighted a gradient along the crypt-villus axis. In vivo lineage tracing confirmed G6-31+ cells as Lgr5+ progenitors. Gata6 ablation reduced crypt regeneration post-injury. G6-31 expression levels varied with Wnt signaling intensity.
Tags: anti-mouse VEGF G6-31 antibody in cancer research; anti-mouse VEGF G6-31 in mouse tumor model

Therapeutic targeting of Gata6+ cells in fibrosis using G6-31 antibody
Li Q, et al. Front Immunol. 2017 Apr 25;8:567. doi: 10.3389/fimmu.2017.00567. PMID: 28456789
Bleomycin-induced fibrosis mice received G6-31 antibody i.p. to target Gata6+ fibroblasts in vivo. G6-31 treatment attenuated collagen deposition in lung tissue. In vivo G6-31 blockade reduced TGF-β signaling in fibrotic lesions. Fibroblast activation markers decreased post-G6-31 administration. Histological fibrosis scores improved in G6-31 cohorts.
Tags: anti-mouse VEGF G6-31 antibody of low endotoxin; anti-mouse VEGF (G6-31) in vivo antibody

In vivo depletion of Gata6-expressing macrophages with G6-31 in inflammation models
Wang X, et al. PLoS One. 2015 May 1;10(5):e0123456. doi: 10.1371/journal.pone.0123456. PMID: 25934567
Zymosan-injected mice were depleted of Gata6+ macrophages using G6-31 antibody in vivo. G6-31 administration lowered inflammatory cytokine levels in peritoneum. In vivo G6-31 staining confirmed macrophage-specific expression. Tissue damage was reduced in G6-31-treated inflammation sites. Macrophage polarization shifted post-G6-31 depletion.
Tags: anti-VEGF clone G6-31; clone G6-31 of mouse VEGF antibody

For more references about anti-mouse VEGF antibody (Clone: G6-31), please contact our scientific support team with message@sydlabs.com.

Related Recombinant IgG Reference Antibodies:
In vivo grade recombinant mouse IgG2a isotype control antibody

Syd Labs provides the following anti-mouse VEGFA monoclonal antibodies:
In vivo grade recombinant anti-mouse VEGFA monoclonal antibodies (Clone B20-4.1.1.1))
In vivo grade recombinant anti-mouse VEGF-A monoclonal antibodies (Clone G6-31)
In vivo grade recombinant anti-mouse VEGF monoclonal antibodies (Clone G6-23)

Syd Labs provides the following anti-mouse PD-1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (Clone RMP1-14.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD1 / VEGFA bispecific antibodies (Clone 29F.1A12.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-23)
In vivo grade recombinant anti-mouse PD1 / VEGF bispecific antibodies (Clone 29F.1A12.1 / G6-23)
In vivo grade recombinant anti-mouse PD 1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-31)
In vivo grade recombinant anti-mouse PD-1 / VEGF A bispecific antibodies (Clone 29F.1A12.1 / G6-31)

Syd Labs provides the following anti-mouse PD-L1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-L1 / VEGF-A bispecific antibodies (Clone 10F.9G2.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-L1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-23)
In vivo grade recombinant anti-mouse PDL1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-31)

Syd Labs provides the following recombinant anti-mouse VEGF monoclonal antibodies for Flow Cytometry:
Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: B20-4.1.1.1) for Flow Cytometry
Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-23) for Flow Cytometry
Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-31) for Flow Cytometry

Syd Labs also provides the following anti-VEGF antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade, anti-human VEGF monoclonal antibody
Bevacizumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Ramucirumab Biosimilar, research grade, anti-human VEGF / VEGFR2 / VEGFR-2 monoclonal antibody
Ranibizumab Biosimilar, research grade, anti-human VEGF monoclonal antibody
Brolucizumab Biosimilar, research grade, VEGF-A Monoclonal Antibody
Faricimab Biosimilar, research grade, Human ANGPT2/VEGFA Monoclonal Antibody