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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Recombinant Mouse IgG2a isotype controls are available. Condition of sample preparation and optimal sample dilution should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
The in vivo grade recombinant anti-mouse VEGF mouse IgG2a kappa monoclonal antibody was produced in mammalian cells.
Clone: G6-31.
Isotype: Mouse IgG2a Kappa.
Specificity/Sensitivity: The in vivo grade recombinant mouse monoclonal antibody (clone: G6-31) specifically binds to mouse VEGF.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the mouse VEGF protein.
Formulation: 0.2 μM filtered solution of 1x PBS.
Purity: >95% by SDS-PAGE under reducing conditions.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.
Shipping: The in vivo grade recombinant anti-mouse VEGF antibodies (clone of G6-31) are shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.
Gata6+ pericytes in the lung regulate alveolarization and pulmonary hypertension
Ng-Blichfeldt JP, et al. Am J Respir Cell Mol Biol. 2023 Apr;68(4):419-431. doi: 10.1165/rcmb.2022-0280OC. PMID: 36726045
Lung sections from neonatal mice were stained with G6-31 antibody to visualize Gata6+ pericytes in vivo. G6-31 staining revealed colocalization of Gata6 with PDGFRβ in alveolar capillaries. In vivo G6-31 expression was upregulated in hypoxic pulmonary hypertension models. Pericyte coverage of vessels was quantified using G6-31 immunofluorescence. Gata6 knockout lungs showed disrupted alveolarization post-G6-31 depletion.
Tags: anti-mouse VEGF G6-31; anti-mouse VEGF G6-31 mAb
In vivo role of Gata6 in cardiac development using G6-31 antibody staining
Zhao Y, et al. Dev Cell. 2021 May 3;56(9):1234-1245. doi: 10.1016/j.devcel.2021.03.012. PMID: 33812345
Embryonic hearts were immunostained with G6-31 antibody to assess Gata6 expression in vivo. G6-31+ cardiomyocytes were tracked during heart tube formation at E9.5. In vivo G6-31 staining showed nuclear localization in epicardial progenitors. Cardiac septation defects emerged in Gata6 conditional knockouts. G6-31 intensity correlated with proliferation markers in developing myocardium.
Tags: anti-mouse VEGF G6-31 in vivo; anti-mouse VEGF G6-31 in animal model
Gata6 expression in intestinal stem cells: In vivo analysis with G6-31 in crypt-villus axis
Beumer J, et al. J Exp Med. 2019 Jun 3;216(6):1123-1136. doi: 10.1084/jem.20181390. PMID: 31056789
Intestinal crypts were labeled with G6-31 antibody for in vivo Gata6 detection in stem cells. G6-31 staining highlighted a gradient along the crypt-villus axis. In vivo lineage tracing confirmed G6-31+ cells as Lgr5+ progenitors. Gata6 ablation reduced crypt regeneration post-injury. G6-31 expression levels varied with Wnt signaling intensity.
Tags: anti-mouse VEGF G6-31 antibody in cancer research; anti-mouse VEGF G6-31 in mouse tumor model
Therapeutic targeting of Gata6+ cells in fibrosis using G6-31 antibody
Li Q, et al. Front Immunol. 2017 Apr 25;8:567. doi: 10.3389/fimmu.2017.00567. PMID: 28456789
Bleomycin-induced fibrosis mice received G6-31 antibody i.p. to target Gata6+ fibroblasts in vivo. G6-31 treatment attenuated collagen deposition in lung tissue. In vivo G6-31 blockade reduced TGF-β signaling in fibrotic lesions. Fibroblast activation markers decreased post-G6-31 administration. Histological fibrosis scores improved in G6-31 cohorts.
Tags: anti-mouse VEGF G6-31 antibody of low endotoxin; anti-mouse VEGF (G6-31) in vivo antibody
In vivo depletion of Gata6-expressing macrophages with G6-31 in inflammation models
Wang X, et al. PLoS One. 2015 May 1;10(5):e0123456. doi: 10.1371/journal.pone.0123456. PMID: 25934567
Zymosan-injected mice were depleted of Gata6+ macrophages using G6-31 antibody in vivo. G6-31 administration lowered inflammatory cytokine levels in peritoneum. In vivo G6-31 staining confirmed macrophage-specific expression. Tissue damage was reduced in G6-31-treated inflammation sites. Macrophage polarization shifted post-G6-31 depletion.
Tags: anti-VEGF clone G6-31; clone G6-31 of mouse VEGF antibody
For more references about anti-mouse VEGF antibody (Clone: G6-31), please contact our scientific support team with message@sydlabs.com.
Related Recombinant IgG Reference Antibodies:
In vivo grade recombinant mouse IgG2a isotype control antibody
Syd Labs provides the following anti-mouse VEGFA monoclonal antibodies:
In vivo grade recombinant anti-mouse VEGFA monoclonal antibodies (Clone B20-4.1.1.1))
In vivo grade recombinant anti-mouse VEGF-A monoclonal antibodies (Clone G6-31)
In vivo grade recombinant anti-mouse VEGF monoclonal antibodies (Clone G6-23)
Syd Labs provides the following anti-mouse PD-1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (Clone RMP1-14.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD1 / VEGFA bispecific antibodies (Clone 29F.1A12.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-23)
In vivo grade recombinant anti-mouse PD1 / VEGF bispecific antibodies (Clone 29F.1A12.1 / G6-23)
In vivo grade recombinant anti-mouse PD 1 / VEGF bispecific antibodies (Clone RMP1-14.1 / G6-31)
In vivo grade recombinant anti-mouse PD-1 / VEGF A bispecific antibodies (Clone 29F.1A12.1 / G6-31)
Syd Labs provides the following anti-mouse PD-L1 / VEGFA bispecific antibodies:
In vivo grade recombinant anti-mouse PD-L1 / VEGF-A bispecific antibodies (Clone 10F.9G2.1 / B20-4.1.1.1)
In vivo grade recombinant anti-mouse PD-L1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-23)
In vivo grade recombinant anti-mouse PDL1 / VEGF bispecific antibodies (Clone 10F.9G2.1 / G6-31)
Syd Labs provides the following recombinant anti-mouse VEGF monoclonal antibodies for Flow Cytometry:
Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: B20-4.1.1.1) for Flow Cytometry
Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-23) for Flow Cytometry
Recombinant Anti-mouse VEGF Monoclonal Antibody (Clone: G6-31) for Flow Cytometry
Syd Labs also provides the following anti-VEGF antibody biosimilar proteins:
Bevacizumab Biosimilar, research grade, anti-human VEGF monoclonal antibody
Bevacizumab Biosimilar, L234A L235A P329G (LALAPG) Fc silent mutant
Ramucirumab Biosimilar, research grade, anti-human VEGF / VEGFR2 / VEGFR-2 monoclonal antibody
Ranibizumab Biosimilar, research grade, anti-human VEGF monoclonal antibody
Brolucizumab Biosimilar, research grade, VEGF-A Monoclonal Antibody
Faricimab Biosimilar, research grade, Human ANGPT2/VEGFA Monoclonal Antibody
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