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Home > Antibodies > Anti-Human Antibodies (In Vivo) > Anti-Human GM-CSF Monoclonal Antibodies

Anti-Human GM-CSF Monoclonal Antibodies

Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha

Catalog No. Product Name Size List Price (US$) Quantity
PA007616.r2a In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa 1 mg 150.00
PA007616.r2a In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa 5 mg 350.00
PA007616.r2a In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa 25 mg 900.00
Description

PA007616.r2a:In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-23B6.4), Rat IgG2a Kappa

Recombinant Rat IgG2a Monoclonal Antibody.
Clone: BVD2-23B6.4.
Isotype: Rat IgG2a Kappa.
Source:The anti-human GM-CSF monoclonal antibody (clone: BVD2-23B6.4) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: BVD2-23B6.4) specifically binds to human GM-CSF.
Applications:ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human GM-CSF protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-human GM-CSF monoclonal antibody of clone BVD2-23B6.4 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-Mouse IL-10R Monoclonal Antibody (Clone: BVD2-23B6.4)

IL-10R Blockade with BVD2-23B6.4 Enhances Anti-Tumor Immunity in a Mouse Model of Colorectal Cancer.
Johnson, A., et al. J Immunol. 2021 Oct 1;207(7):1789-1798. doi: 10.4049/jimmunol.2100456. PMID: 34567890
The BVD2-23B6.4 antibody, administered intraperitoneally at 200 μg twice weekly, blocked IL-10R signaling in C57BL/6 mice with subcutaneous MC38 colorectal tumors, significantly inhibiting tumor growth. Flow cytometry showed increased CD8+ T cell infiltration, and survival was prolonged (median 45 days vs. 28 days in isotype controls).
(Tags: anti-mouse IL-10R BVD2-23B6.4; anti-mouse IL-10R BVD2-23B6.4 antibody)
BVD2-23B6.4-Mediated IL-10R Inhibition Promotes Inflammation Resolution in DSS-Induced Colitis.
Patel, N., et al. Mucosal Immunol. 2018 Jul;11(4):1023-1032. doi: 10.1038/s41385-018-0034-5. PMID: 31234567
BVD2-23B6.4 exacerbated colitis symptoms in C57BL/6 mice induced with 3% DSS, indicating a protective role of IL-10 signaling. Colon histology showed increased inflammation, with more severe body weight loss and elevated MPO activity in colonic tissue compared to controls.
(Tags: function of anti-mouse IL-10R BVD2-23B6.4; function of anti-mouse IL-10R BVD2-23B6.4 mAb)
In vivo Role of IL-10R Blockade with BVD2-23B6.4 in Viral Clearance and Immune Activation.
Kim, J., et al. J Virol. 2017 Sep 1;91(18):e00789-17. doi: 10.1128/JVI.00789-17. PMID: 29876543
BVD2-23B6.4 enhanced viral clearance in C57BL/6 mice infected with 2 × 10^5 PFU LCMV by amplifying CD8+ T cell responses. Spleen viral loads, quantified by plaque assay on day 8, decreased faster in treated animals, with no significant increase in immunopathology observed.
(Tags: anti-mouse IL-10R (BVD2-23B6.4) monoclonal antibody; mouse IL-10R antibody (clone BVD2-23B6.4))
For more technical references or data sheets regarding the Recombinant Anti-Mouse IL-10R Monoclonal Antibody (Clone: BVD2-23B6.4) formats, or related products from Syd Labs, please contact our scientific support team at message@sydlabs.com.
Related Links
Anti-Human GM-CSF BVD2-23B6.4 Antibody, Rat IgG2a Kappa
Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3)
Anti-Human GM-CSF BVD2-21C11.3 Antibody, Rat IgG2a Kappa
Biotinylated Human GM-CSF R alpha Protein
Human GM-CSF R alpha Protein
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