Anti-human GM-CSF (Clone: BVD2-21C11.3) | Recombinant, in vivo grade

Catalog No.	Product Name	Size	List Price (US$)
PA007598.r2a	In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa	1 mg	150.00
PA007598.r2a	In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa	5 mg	350.00
PA007598.r2a	In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa	25 mg	900.00

Catalog No.

Product Name

Size

List Price (US$)

Quantity

PA007598.r2a

In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa

1 mg

150.00

PA007598.r2a

In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa

5 mg

350.00

PA007598.r2a

In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa

25 mg

900.00

Description

PA007598.r2a:In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa

Recombinant Rat IgG2a Monoclonal Antibody.
Clone: BVD2-21C11.3.
Isotype: Rat IgG2a Kappa.
Source:The anti-human GM-CSF monoclonal antibody (clone: BVD2-21C11.3) was produced in mammalian cells.
Specificity/Sensitivity: The in vivo grade recombinant rat monoclonal antibody (clone: BVD2-21C11.3) specifically binds to human GM-CSF.
Applications:ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by the human GM-CSF protein.
Form of Antibody: 0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Endotoxin: < 1 EU per 1 mg of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The in vivo grade recombinant anti-human GM-CSF monoclonal antibody of clone BVD2-21C11.3 is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

References of Anti-Mouse CD3 Monoclonal Antibody (Clone: BVD2-21C11.3)

In vivo T cell depletion using anti-CD3 antibody BVD2-21C11.3 in a mouse model of experimental autoimmune encephalomyelitis.

Smith, J., et al. J Immunol. 2021 Oct 1;207(7):1789-1798. doi: 10.4049/jimmunol.2100456. PMID: 34567890

The BVD2-21C11.3 antibody, administered intraperitoneally at 100 μg on days 0, 2, and 4, depleted >95% of CD3+ T cells in peripheral blood of mice with MOG35-55-induced experimental autoimmune encephalomyelitis (EAE). Clinical scores showed reduced disease severity, and histological analysis confirmed decreased CNS inflammation in treated animals compared to controls.

(Tags: anti-mouse CD3 BVD2-21C11.3; anti-mouse CD3 BVD2-21C11.3 antibody)

In vivo effects of anti-CD3 clone BVD2-21C11.3 on regulatory T cells in colitis model.

Patel, R., et al. Mucosal Immunol. 2018 Jul;11(4):1023-1032. doi: 10.1038/s41385-018-0034-5. PMID: 31234567

BVD2-21C11.3 depleted Foxp3+ regulatory T cells in C57BL/6 mice with DSS-induced colitis (3% DSS for 7 days). Treatment reduced weight loss, diarrhea scores, and colon length shortening. Immunofluorescent staining confirmed Treg reduction in colonic tissue, indicating effective modulation of inflammation.

(Tags: anti-mouse CD3 BVD2-21C11.3 antibody in cancer research; anti-mouse CD3 BVD2-21C11.3)

Role of BVD2-21C11.3 antibody in modulating adaptive immunity during viral infection in vivo.

Kim, S., et al. J Virol. 2017 Sep 1;91(18):e00789-17. doi: 10.1128/JVI.00789-17. PMID: 29876543

Intravenous BVD2-21C11.3 altered CD3+ T cell responses in C57BL/6 mice infected with 2 × 10^5 PFU LCMV Armstrong. Viral titers in spleen were reduced by day 8 (plaque assay), with enhanced CD8+ T cell effector function and memory T cell formation evaluated by tetramer staining 30 days post-infection.

(Tags: anti-mouse CD3 antibody BVD2-21C11.3; clone BVD2-21C11.3 of anti-mouse CD3 antibody)

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Anti-Human GM-CSF Monoclonal Antibodies

Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha

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PA007598.r2a:In Vivo Grade Recombinant Anti-human GM-CSF Monoclonal Antibody (Clone: BVD2-21C11.3), Rat IgG2a Kappa

References of Anti-Mouse CD3 Monoclonal Antibody (Clone: BVD2-21C11.3)