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Background Information:
AN2728 (Crisaborole) is a non-steroidal, topically administered, boron-containing, anti-inflammatory compound that inhibits Phosphodiesterase 4 (PDE4), mainly acting on Phosphodiesterase 4B (PDE4), activity and thereby suppresses the release of tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines, proteins believed to be involved in the immune response and inflammation. The boron atom helps penetrate the skin and is essential for its binding activity.
Reference:
1. Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2010 Jan-Feb; 32(1):47-86.
2. Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Nov; 31(9):597-633.
APIM050358: AN2728 (CRISABOROLE)
CAS No.: 906673-24-3.
Molecular Formula: C14H10BNO3.
Molecular Weight: 251.08.
Purity: >99.5% by HPLC.
QC: HPLC, 1HNMR and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO, alcohols and acetone.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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