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Conditions of optimal AKR1C4 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-?-Androstan-3-?,17-?-diol (3-?-diol). In addition, AKR1C4 also has some 20-?-Hydroxysteroid Dehydrogenase activity.
BP001679-ENZ-145: Recombinant Human Aldo-Keto Reductase 1C4 (AKR1C4) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 343 amino acids (1-323) and having a molecular mass of 39.2 kDa. The AKR1C4 is fused to a 20 amino acid His-Tag at N-terminus.
Specific activity: approximately > 0.6 units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25C. Specific activity was expressed as units/mg protein.
Purity: >90% by SDS-PAGE.
Formulation: AKR1C4 protein 1 ug/ml is supplied in 20 mM Tris-HCL, pH-8, 0.1 M NaCl, 1 mM DTT and 20% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other AKR1C4 Enzymes:
Recombinant Human AKR1C4 Protein
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