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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal AKR1B1 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
AKR1B1 is part of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. AKR1B1 catalyzes the reduction several aldehydes, including the aldehyde form of glucose, and thus involved in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. AKR1B1 catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Transgenic mice over expressing human aldose reductase show that AKR1B1 is a key player in ischemic injury and impairment of functional and metabolic recovery after ischemia. Aldose Reductase is an obligatory mediator of TNF-alpha signaling leading to an increase in the expression of adhesion molecules and increased binding of monocytes to the endothelium. AKR1B1 is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.
BP000858-ENZ-390: Recombinant Human Aldose Reductase
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 316 amino acids having a molecular mass of 35.8 kDa.
Specific activity : approximately 0.5 - 0.6 units/mg.
Purity > 95%, by SDS-PAGE.
Formulation: The 1 ug/ml protein solution contains 20 mM Tris-HCl buffer pH 8, 10% glycerol, and 1mM DTT.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other AKR1B1 Enzymes:
Recombinant Human AKR1B10
AKR1B1 Antibodies:
AKR1B1 Polyclonal Antibody
AKR1B1 Polyclonal Antibody
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