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Home > Antibodies > Research-Grade Biosimilars > Aflibercept Biosimilar

Aflibercept Biosimilar

Zaltrap Biosimilar, Eylea Biosimilar, ziv-aflibercept, VEGF Receptors 1 and 2 Fc Fusion Protein

Catalog No. Product Name Size List Price (US$) Quantity
C013P Aflibercept Biosimilar 1 mg 500.00
C013P Aflibercept Biosimilar 5 mg 1000.00
C013P Aflibercept Biosimilar 20 mg 2500.00
Description

What is research grade Aflibercept biosimilar? Research grade Aflibercept biosimilar has the same amino acid sequence as Aflibercept (trade name Eylea), a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). It inhibits vascular endothelial growth factor (VEGF), and is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Aflibercept is a dimeric glycoprotein with a molecular weight of 96.9 kilo Daltons (kDa). Glycosylation adds its molecular weight to 115 kDa in total. Ziv-aflibercept (trade name Zaltrap) was developed as an injection for treatment of metastatic colorectal cancer.

C013P: Aflibercept Biosimilar

Recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).
Source: The aflibercept biosimilar protein was produced in the Zaltrap / Eylea biosimilar CHO stable cell line.
Specificity/Sensitivity: The aflibercept biosimilar protein specifically binds to the human VEGF.
Applications: Functional assays, and those assays for studying biological pathways affected by aflibercept.
Form of Protein: 0.2 uM filtered solution, pH 6.1, no stabilizers or preservatives.
Endotoxin: < 0.1 EU per 1 ug of the protein by the LAL method.
Purity: >95% by SDS-PAGE under reducing conditions and HPLC.

Shipping: The research grade aflibercept biosimilar protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month from date of receipt, 2 to 8°C as supplied.

Syd Labs also provides the following VEGF-A antibody biosimilar:
Lucentis Biosimilar  (Fab produced in E. coli)
Bevacizumab Biosimilar (complete antibody produced in CHO)

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