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Conditions of optimal ADAM12 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
ADAM12 is part of the A Disintegrin and Metalloprotease protein family which are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis.
ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).
BP002104-PRO-474: Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S-Isoform (ADAM12) Protein
Source: E. Coli-derived.
Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S-Isoform (ADAM12) protein is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The ADAM12 solution contains 20 mM Tris-HCl and 50% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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