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4-1BBL Protein

4-1BB Ligand, CD137L, CD137-L, TNFSF9, Tumor Necrosis Factor (ligand) Superfamily Member 9

Catalog No. Product Name Size List Price (US$) Quantity
BP000093-CYT-149 Recombinant Human 4-1BB Ligand 20 ug 160.00
BP000093-CYT-149 Recombinant Human 4-1BB Ligand 1 mg 2700.00
Description

Introduction
4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor (TNF) ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin

BP000093-CYT-149: Recombinant Human 4-1BB Ligand

Source: E. coli-derived.
A single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 19.5 kDa.
Fully biologically active when compared to standard. Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10ug/ml corresponding to a Specific Activity of 100,000-200,000 IU/mg.
Purity > 95%, by SDS-PAGE.
Formulation: Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Reconstitution: It is recommended to reconstitute the lyophilized 4 1BBL in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other 4-1BBL Protein:
Recombinant Human 4-1BB Ligand, His Tag

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