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Home > Chemicals > Inhibitors, Activators, Antagonists, and Agonists > A-Z Inhibitors, Activators, Antagonists, and Agonists > XL184 (CABOZANTINIB) (FREE BASE)

XL184 (CABOZANTINIB) (FREE BASE)

Cabozantinib, BMS907351, BMS-907351

Catalog No. Product Name Size List Price (US$) Quantity
APIM050263 XL184 (CABOZANTINIB) (FREE BASE) 50 mg 100.00
APIM050263 XL184 (CABOZANTINIB) (FREE BASE) 200 mg 230.00
Description

Background Information:

XL184 (Cabozantinib) is an orally active, multitargeted inhibitor of tumor growth, metastasis and angiogenesis, simultaneously targeting c-MET, RET and VEGFR2 with IC50s at low nM.

Reference:

1. Kurzrock, R., et al., J Clin Oncol, 2011 Jul 1; 29(9): 2662-6.
2. Durante, C., et al., Expert Opin Investig Drugs, 2011 May; 20 (3): 403-413.
3. You WK, et al. Cancer Res, 2011, 71(14), 4758-4768.

APIM050263: XL184 (CABOZANTINIB) (FREE BASE)

CAS No.: 849217-68-1.
Molecular Formula: C28H24FN3O5.
Molecular Weight: 501.5.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: 1HNMR, HPLC/MS, and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.

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