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Background Information:
XL184 (Cabozantinib) is an orally active, multitargeted inhibitor of tumor growth, metastasis and angiogenesis, simultaneously targeting c-MET, RET and VEGFR2 with IC50s at low nM.
Reference:
1. Kurzrock, R., et al., J Clin Oncol, 2011 Jul 1; 29(9): 2662-6.
2. Durante, C., et al., Expert Opin Investig Drugs, 2011 May; 20 (3): 403-413.
3. You WK, et al. Cancer Res, 2011, 71(14), 4758-4768.
APIM050263: XL184 (CABOZANTINIB) (FREE BASE)
CAS No.: 849217-68-1.
Molecular Formula: C28H24FN3O5.
Molecular Weight: 501.5.
Purity: >99.5% (HPLC at 214 and 254 nm).
QC: 1HNMR, HPLC/MS, and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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