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Background Information:
WEHI-539 is an inhibitor of BCL-2 family proteins, binding potently and selectively to BCL-XL with an IC50 of ~1.1 nM. It was the first small molecule that selectively antagonizes the prosurvival activity of BCL-XL with nM potency.
Reference:
1. Lessene G, et al. Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol. 2013 Jun;9(6):390-7.
APIM050288: WEHI-539
CAS No.: 1431866-33-9.
Molecular Formula: C31H29N5O3S2?3HCl?H2O.
Molecular Weight: 711.1.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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