Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
Extracellular signal regulated kinase (ERK) is a pivotal enzyme in the pathway downstream of Ras, Raf, and MEK, acting as a central link between multiple signaling pathways. VX-11e (or ERK 11e) is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki < 2 nM, exhibiting potent cellular activity (IC50=48 nM in an HT29 cell proliferation assay). It is highly selective against a panel of more than 140 other kinases - most notably, GSK3 (Ki = 400nM), AURA (Ki = 540nM), CDK2 (Ki = 850nM), FLT3 (Ki = 1400nM), ROCK1 (Ki = 1400nM), and JNK3 (Ki = 1400nM).
Reference:
1. A.M.Aronov, et al, Structure-Guided Design of Potent and Selective Pyrimidyl pyrrole Inhibitors of Extracellular Signal Regulated Kinase(ERK) Using Conformational Control, J.Med.Chem.2009,52,6362–6368.
APIM050258: VX-11E
CAS No.: 896720-20- 0.
Molecular Formula: C24H20Cl2FN5O2?0.1HCl.
Molecular Weight: 505.
Purity: >99% chem and optical purity (HPLC and Chiral HPLC).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2025 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.
Friend Link: Ushelf