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Background Information:
Vorinostat (SAHA) is a small molecule inhibitor of histone deacetylase (HDAC), inhibiting class I and II HDAC with Ki at low nM.
Reference:
1. Kirschbaum M, Frankel P, et al., Phase II Study of Vorinostat for Treatment of Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma and Mantle Cell Lymphoma, J Clin Oncol. 2011 Feb 7. [Epub ahead of print].
2. Stathis A, Hotte S, Chen EX, et al., Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas, Clin Cancer Res. 2011 Jan 28. [Epub ahead of print].
APIM050345: VORINOSTAT
CAS No.: 149647-78-9.
Molecular Formula: C14H20N2O3.
Molecular Weight: 264.3.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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