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Background Information:
Varespladib (LY315920) is an inhibitor of human and mouse sPLA2 group IIA, V, and X enzymes with IC50 values in the low nM range.
Reference:
1. DW Snyder, et al., Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI., J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.
2. H. Fraser, et al., Varespladib (A-002), a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in ApoE-/- mice, J Cardiovasc Pharmacol. 2009 Jan;53(1):60-5.
APIM050363: VARESPLADIB (LY315920)
CAS No.: 172732-68-2.
Molecular Formula: C21H20N2O5.
Molecular Weight: 380.4 (or refer to certificate of analysis, batch-specific).
Purity: 99.9% (by HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR and Quantitative Elemental Analysis.
Solubility: Refer to Certificate of Analysis.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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