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Background Information:
A potent and selective inhibitor (antagonist) of VEGFR (vascular endothelial growth factor receptor), EGFR (epidermal growth factor receptor) and RET (Rearranged during Transfection) tyrosine kinases.
Reference:
1. Deshpande HA, Gettinger SN, Sosa JA. Targeted therapy for thyroid cancer: An updated review of investigational agents. Curr Opin Investig Drugs. 2010 Jun;11(6):661-8.
2. Scagliotti G, Govindan R. Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer. Oncologist. 2010;15(5):436-46.
3. Rossi A, Maione P, Sacco PC, Ambrosio R, Falanga M, Gridelli C. Vascular endothelial growth factor receptor as target for advanced non-small cell lung cancer therapy. Curr Drug Targets. 2010 Jul;11(7):865-8784.
APIM050252: VANDETANIB
CAS No.: 443913-73-3.
Molecular Formula: C22H24BrFN4O2.
Molecular Weight: 475.4.
Purity: >99% (HPLC).
QC: 1HNMR, HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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