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Background Information:
Uprosertib (GSK2141795) is an orally bioavailable, selective and ATP-competitive pan-Akt (PKB) inhibitor, potently inhibiting Akt 1, 2, 3, and Akt 1 E17K mutation with IC50s of 0.066 nM, 2 nM, 1.4 nM, 1.5 nM, and 0.2nM, respectively.
Reference:
1. Recrystallized Free base, confirmed by a perfect high-precision Quantitative Elemental Analysis.
APIM050251: UPROSERTIB (GSK2141795)
CAS No.: 1047634-65-0 (free base) 1047635-80-2 (HCl salt).
Molecular Formula: C18H16Cl2F2N4O2.
Molecular Weight: 429.2.
Purity: 99.5% chem purity (HPLC at 214 and 254 nm), 100% optical purity (Chiral HPLC), [α]20D = +5.4 o (c 1.0, MeOH).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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