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Background Information:
Tubacin is a specific inhibitor of HDAC6, one of 11 known human HDACs. Besides deacetylating tubulin, HDAC6 binds both polyubiquinated proteins (i.e., proteins marked for degradation by attached ubiquitin "flags") and dynein (a protein motor associated with microtubules), bringing the two together to help the cell clean house. This takes place through a recently described cell structure called the aggresome. There is growing evidence to support the relevance of HDAC6 and its non-histone substrates as a target for other cancers, including breast cancer. In addition, HDAC6 also targets another cellular protein known as Hsp90, a protein critical in helping other proteins achieve their correct conformation, including proteins implicated in many forms of cancer.
Reference:
1. Barua, Sutapa; Rege, Kaushal. The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes. Biomaterials (2010), 31(22), 5894-5902.
2. Hong, Jian; Xu, Xin; Das, Debasis; Yang, Pengyu; Chen, Shu-Hui; Li, Ge. A new approach to tubacin. Letters in Organic Chemistry (2010), 7(1), 50-53.
3. Bradner, James E.; West, Nathan; Grachan, Melissa L.; Greenberg, Edward F.; Haggarty, Stephen J.; Warnow, Tandy; Mazitschek, Ralph. Chemical phylogenetics of histone deacetylases. Nature Chemical Biology (2010), 6(3), 238-243.
APIM050343: TUBACIN
CAS No.: 537049-40-4.
Molecular Formula: C41H43N3O7S.
Molecular Weight: 721.9.
Purity: 99% chemical purity (HPLC), >99% optical purity (Chiral HPLC, [α]20D = - 42.3 o (c 0.442, DMSO)).
QC: Achiral and Chiral HPLCs, MS and 1HNMR, Elemental Analysis and optical rotation Reports.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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