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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal SCG5 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Secretogranin-5 (SCG5) is a single non-glycosylated polypeptide that is a member of the 7B2 family. SCG5 is widely distributed in neuroendocrine tissues. SCG5 binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. It functions as a chaperone protein for the proprotein convertase PC2, preventing its premature activation in the regulated secretory pathway. It is also required for cleavage of PCSK2 but does not appear to be involved in its folding. It plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
BP001779-C634: Recombinant Human Secretogranin-5 (SCG5) Protein
Source: HEK 293-derived.
Recombinant Human Secretogranin-5 (SCG5) Protein is expressed with sequence (Tyr27-Glu212) of Human SCG5 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: 0.2 um filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 10% Glycerol, pH 8.0.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other SCG5 Proteins:
Recombinant Human SCG5 Protein
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