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Background Information:
Romidepsin is an inhibitor of HDAC (Histone Deacetylases). It potently inhibits HDAC1 and HDAC2 with IC50 of 1.6 nM and 3.9 nM, respectively, and is relatively weak in inhibiting HDAC4 and HDAC6 with IC50 of 25 nM and 790 nM, respectively. It inhibits the growth of U-937, K562, and CCRF-CEM cells with IC50 of 5.92 nM, 8.36 nM, and 6.95 nM, respectively. Romidepsin induces apoptosis in chronic lymphocytic leukemia (CLL) cells at a concentration corresponding to that at which H3 and H4 acetylation and HDAC inhibition occurs, selectively involving activation of caspase 8 and effector caspase 3, as well as down-regulation of c-FLIP protein.
APIM050341: ROMIDEPSIN
CAS No.: 128517-07-7.
Molecular Formula: C24H36N4O6S2.
Molecular Weight: 540.7.
Purity: >99% (HPLC at 220 nm).
QC: HPLC-MS and NMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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