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Background Information:
Regorafenib is an orally active multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-β) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC50s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively.
Reference:
1. Wilhelm, SM., et al., Int J Cancer, 2011 Jul 1; 129(1): 245-55.*Regorafenib Monohydrate (C21H15ClF4N4O3?H2O) is the clinically active formulation format.
APIM050234: REGORAFENIB
CAS No.: 755037-03-7.
Molecular Formula: C21H15ClF4N4O3 ? H2O.
Molecular Weight: 500.83.
Purity: >99.5% chemical purity (HPLC).
QC: 1HNMR, HPLC and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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