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Background Information:
Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest, and is used for induced synthetic lethality in cancer cells.
Reference:
1. R. Rodriguez, et al, Small-molecule–induced DNA damage identifies alternative DNA structures in human genes, Nature Chemical Biology, 8 (3), 301–310 (2012).
2. R. Rodriguez, et al, A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres, J. Am. Chem. Soc., 2008, 130 (47), 15758-15759.
APIM050308: PYRIDOSTATIN
CAS No.: 1085412-37-8.
Molecular Formula: C31H32N8O5 ? 5.5HCl ? 5.5H2O.
Molecular Weight: 896.3.
Purity: >97% by HPLC detected at 214 and 254 nm.
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO and water.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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