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Background Information:
A selective inhibitor of B-RAF protein kinase carrying V600E mutation with an IC50 of 44 nM.
Reference:
1. Bollag, G., et al., Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma, Nature, 467, 596-9 (2010).
APIM050228: PLX4032
CAS No.: 1029872-54-5.
Molecular Formula: C23H18ClF2N3O3S.
Molecular Weight: 489.9.
Purity: 99.5% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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