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Background Information:
PF-8380 is an orally bioavailable, potent and competitive inhibitor of autotaxin (IC = 2.8 nM in enzyme assay; 101 nM in human whole blood). It directly inhibits autotaxin activity, modulating lysophosphatidic acid (LPA) levels in vivo and in vitro, and reduces LPA levels both in plasma and at site of inflammation.
APIM050274: PF-8380
CAS No.: 1144035-53-9.
Molecular Formula: C22H21Cl2N3O5.
Molecular Weight: 478.3 (or refer to Certificate of Analysis, batch-specific).
Purity: >99% by HPLC (214 and 254 nm).
QC: HPLC, NMR and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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