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Background Information:
PBF-509 (Taminadenant, NIR178), an oral immunotherapy agent, is a potent and selective A2A (Adenosine 2A) receptor antagonist, binding to human A2A receptor with a Ki value of 12 nM. It inhibits A2AR expressed on T lymphocytes, thus abrogates the adenosine/ A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. It is also reported as a potential pro-dopaminergic drug for Parkinson’s disease (PD) management.
APIM050059: PBF-509 (TAMINADENANT)
CAS No.: 1337962-47-6.
Molecular Formula: C10H8BrN7.
Molecular Weight: 306.1.
Purity: 99.5% by HPLC.
QC: HPLC, 1H-NMR, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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