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Background Information:
Olmutinib (BI 1482694, HM61713) is a third-generation, orally bioavailable and irreversible Tyrosine Kinase Inhibitor, potently and selectively targeting EGFR mutants with Ki values of ~10 nM (in vitro cell assays, against sensitizing (Del19, L858R) and resistance (T790M) EGFR mutations), highly selective over Wt EGFR (Ki = >2000nM, >200-fold selectivity). It is an FDA -designated Breakthrough Therapy for lung cancer.
APIM050212: OLMUTINIB (BI 1482694, HM71224)
CAS No.: 1353550-13-6.
Molecular Formula: C26H26N6O2S.
Molecular Weight: 486.6.
Purity: >99.5% by HPLC.
QC: HPLC-MS, 1H-NMR, and quantitative elemental analysis report.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.
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