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Conditions of optimal OCM1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Oncomodulin is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing oncomodulin access to the cytosolic compartment. Oncomodulin-1, also called OM, Parvalbumin beta, OCM, OCM1 and OCMN, is a member of the superfamily of calmodulin proteins. It is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OCM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.
BP001133-C245: Recombinant Human Oncomodulin-1 (OCM1) Protein
Source: E. coli-derived.
Recombinant Human Oncomodulin-1 (OCM1) Protein is expressed with sequence (Ser2-Ser109) of Human OCM fused with a His tag at the C-terminus.
Purity: > 95% by reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 50 mM Tris, 100 mM NaCl, pH 7.5.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other OCM1 Proteins:
Recombinant Human OCM1 Protein
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