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Background Information:
Obatoclax is an orally bioavailable inhibitor of B-cell lymphoma-2 (BCL-2) family proteins.
Reference:
1. M. Konopleva, et al, "Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)". Cancer Research (2008) 68 (9): 3413–3420.
2. S. A. Parikh, et al, "Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis". Clinical Lymphoma, Myeloma & Leukemia, 10 (4): 285–289 (2010).
APIM050286: OBATOCLAX
CAS No.: 803712-67-6.
Molecular Formula: C20H19N3O.
Molecular Weight: 317.4.
Purity: 99% (HPLC), 99% Cis isomer.
QC: HPLC, 1HNMR, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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