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Background Information:
A potent, selective, and orally bioavailable Smoothened (Hedgehog Signaling Pathway) antagonist, currently in clinical trials. Diphosphate salt offers a much better bioavailability than free base (Ref. 1).
Reference:
1. Pan, S., et al, Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist, ACS Med. Chem. Lett., 2010, 1 (3), pp 130–134.
2. 0 equivalent phosphate is confirmed by a spot-on Quantitative Elemental Analysis - the most rigorous standard, achieved ONLY by Chemietek. This product is functionally equivalent to the very same material from Novartis (The drug developer) per our clients.
APIM050353: NVP-LDE225 DIPHOSPHATE SALT (ERISMODEGIB, SONIDEGIB)
CAS No.: 1218778-77-8.
Molecular Formula: C26H26F3N3O3 ? 2H3PO4.
Molecular Weight: 681.5.
Purity: 99.9% (HPLC at 214 and 254 nm).
QC: HPLC, 1HNMR and Quantitative Elemental Analysis Report.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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