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Conditions of optimal NMDAR1 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
The NMDA receptor (NMDAR) is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties.1 It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'.2 The gene is a candidate for the site of the mutation in torsion dystonia.3, 4 The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.
PA000198-PA1222: NMDAR1 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: Rat, mouse. No cross reactivity with other proteins.
Applications: WB 1-2ug/ml IHC-P 0.5-1 ug/ml.
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human NMDAR1, identical to the related rat and mouse sequence.
Purification: Immunogen affinity purified.
Reactivity: Human, Mouse, Rat.
Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Other NMDAR1 Antibodies:
NMDAR1 Polyclonal Antibody
NMDAR1 Polyclonal Antibody
NMDAR1 (Ab-897) Polyclonal Antibody
NMDAR1 (Ab-896) Polyclonal Antibody
NMDAR1 (Ab-890) Polyclonal Antibody
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