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Background Information:
A synthetic inhibitor of histone deacetylase (HDAC), Preferentially inhibits HDAC1 (IC50=300nM) over HDAC3 (IC50=8µM). Has no inhibitory activity towards HDAC8 (IC50>100µM).
Reference:
1. Rosato, R.R., et al.; The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1: Cancer Res. 63, 3637 (2003).
2. Simonini, M.V., et al., The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases, PNAS, 103, 5, 1587-1592, (2006).
APIM050339: MS-275
CAS No.: 209783-80-2.
Molecular Formula: C21H20N4O3 ? 0.2H2O.
Molecular Weight: 380.0.
Purity: >99% (HPLC).
QC: 1HNMR, HPLC.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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