Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
|---|
Conditions of optimal MMP12 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endo-peptidases which degrade components of the extracellular matrix (ECM). MMP-12 (macrophage elastase) is found in macrophages and its expression can be induced by cytokines. MMP 12 plays essential roles in various physiological processes and pathological processes. MMP-12 is responsible for cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be part in tissue injury and remodeling and has significant elastolytic activity. MMP-12 is related to the pathogenesis of aortic aneurysms and in the development of pulmonary emphysema MMP-12 is a potent proinflammatory and oncogenic molecule MMP-12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.
BP001323-C375: Recombinant Human Matrix Metalloproteinase-12 (MMP12) Enzyme
Source: HEK 293-derived.
Recombinant Human Matrix Metalloproteinase-12 (MMP12) Enzyme is a secreted protein with sequence (Gly106-Cys470) of human MMP-12 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: 0.2 um filtered solution of 20 mM MES, 150 mM NaCl, 0.05% Brij35, pH 5.5.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
MMP-12 Antibodies:
MMP12 (Cleaved-Glu106) Polyclonal Antibody
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.