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Background Information:
MLN4924 is a small molecule inhibitor of the NEDD8-Activating Enzyme (NAE), a key component of the protein homeostasis pathway. It is the first small molecule inhibitor specifically targeting this class of enzyme to be studied clinically, and is currently being examined in Phase I clinical trials.
Reference:
1. *monohydrate (1.0 H2O), confirmed by a spot-on Quantitative Elemental Analysis.
APIM050050: MLN4924 (PEVONEDISTAT)
CAS No.: 905579-51-3.
Molecular Formula: C21H25N5O4S ? H2O.
Molecular Weight: 461.5.
Purity: 99.9% chemically and stereomerically pure by achiral and chiral HPLCs.
QC: MS, 1HNMR, Achiral and Chiral HPLCs + Quantitative Elemental Analysis.*.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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