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Background Information:
MK-5108 (VX-689) is a potent, selective and ATP competitive inhibitor of Aurora A with IC50 < 1 nM, highly selective (220- and 190-fold) against Aurora B and C, respectively. It is currently in clinical evaluations.
Reference:
1. T Shimomura, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol. Cancer Ther. 2010, 9(1), 157-166.
APIM050201: MK-5108
CAS No.: 1010085-13-8.
Molecular Formula: C22H21ClFN3O3S ? 1.9HCl.
Molecular Weight: 531.2.
Purity: 99.5% Purity (HPLC, detected at 214, 254 and 280 nm).
QC: HPLC, 1HNMR and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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