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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal METAP Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Methionine aminopeptidase 1, METAP, also named MAP 1, MetAP 1, Peptidase M 1, is a member of the M24 family of metalloproteases. METAPs play a central role for protein maturation as they remove the initiator Met residue from newly synthesized proteins and are essential for cell growth. Three METAP genes (METAP1, METAP2 and MAP1D) have been identified in the human genome. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. Fumagillin, a natural compound, covalently modifies an active His residue of METAP2 and prevents the vascularization and metasis of tumors.
BP001316-C151: Recombinant E.coli METAP (Methionine aminopeptidase 1)
Source: E. coli-derived.
Purity > 95%, by reducing SDS-PAGE and SEC-HPLC.
Formulation: Lyophilized at 1 ug/ml in 20 mM PBS.
Reconstitution: We recommend a quick spin followed by reconstitution of Recombinant E. coli METAP in sterile 18 MΩ-cm H2O not less than 100 ug/ml, which can then be further diluted to working solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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