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Background Information:
LY-3177833 (optically pure) is a clinical stage, orally available, potent and selective inhibitor of CDC7 (Cell Division Cycle 7-related Protein Kinase), inhibiting CDC7/DBF4 I and pMCM2 (S53) with IC50 values of 3.3 nM and 290 nM, respectively. The inhibition profoundly impacts chromosome dynamics. Broad antitumor activity was associated with robust dose/exposure-dependent in vivo target inhibition in mouse xenograft models. In addition, the preclinical profile of the compound was different from nonselective CDC7 inhibitors and cytotoxic agents, which supports its clinical development with a continuous dosing regimen (ref. 1).
Reference:
1. Buyer Beware: Be careful the poor optical purity (partially racemized with significant wrong isomer content) LY-3177833 on market, without Chiral HPLC analysis.
APIM050190: LY-3177833 (LY3177833)
CAS No.: 1627696-51-8.
Molecular Formula: C16H12FN5O.
Molecular Weight: 309.3 (or refer to Certificate, batch-specific).
Purity: >99.5% chem and Optical Purity.
QC: HPLC-MS, 1H-NMR, Chiral HPLC, and Quantitative Elemental Analysis Report.
Solubility: Refer to Certificate.
Storage: Refer to Certificate.
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