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Conditions of optimal LRRC4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Leucine-Rich Repeat-Containing Protein 4 (LRRC4) is a 55 kDa type I transmembrane protein. LRRC4 is a member of the NGL family of synaptic LRR adhesion molecules. Human LRRC4 cDNA encodes 653 amino acids (aa) that includes a signal sequence, extracellular domain (ECD), transmembrane domain, and cytoplasmic domain. The ECD contains nine LRRs, one C2 type Ig likedomain, and one Thr-rich segment. LRRC4 is predominantly expressed in the brain on neurons and astrocytes as a ligand for Netrin-G2 on the dendritic surface of synaptic neurons. LRRC4 is proposed to regulate the formation of excitatory synapses. The addition of soluble LRRC4 to cultured neurons can reduce excitatory synapse formation.
BP001761-C486: Recombinant Human Leucine-Rich Repeat-Containing Protein 4 (LRRC4) Protein
Source: HEK 293-derived.
Recombinant Human Leucine-Rich Repeat-Containing Protein 4 (LRRC4) Protein is a secreted protein with sequence (Ala39-Lys527) of Human LRRC4 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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