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Background Information:
LOXO-101 (Larotrectinib) is an oral, potent and selective ATP-competitive pan-TRK inhibitor, with sub-nanomolar potency in IC50 values for all three TRK family members (TrkA, TrkB and TrkC), and >100-fold selectivity over other kinases. Displays robust in vitro and in vivo antitumor activities. It is currently in clinical evaluation.
APIM050183: LOXO-101 (LAROTRECTINIB)
CAS No.: 1223403-58-4.
Molecular Formula: C21H22F2N6O2?1/2H2O.
Molecular Weight: 437.4.
Purity: 99.9% chemical and stereomerical purity by achiral and chiral HPLCs.
QC: Achiral and Chiral HPLCs, 1H-NMR, and Elemental Analysis Report.
Solubility: Refer to certificate of analysis.
Storage: Refer to certificate of analysis.
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