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Conditions of optimal ILT4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
The immunoglobulin-like transcript (ILT) family canactivating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). ILT4 (also known as LIR-2 and LILRB2) is a type I transmembrane protein. ILT4 expressedprimarily on monocytes and dendritic cells (DC). Human ILT4 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain(ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. ILT4 binds to Classical MHC proteins. Ligation of ILT4 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. ILT4 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
BP001389-C485: Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) Protein
Source: HEK 293-derived.
Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) Protein is a secreted protein with sequence (Gln22-His458) of Human LILRB2 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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