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Background Information:
Encorafenib (LGX818) is a selective ATP-competitive RAF kinase inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, Encorafenib was shown to decrease phosphorylation of the B-Raf substrate MEK.
APIM050037: LGX818 (ENCORAFENIB)
CAS No.: 1269440-17-6.
Molecular Formula: C22H27ClFN7O4S.
Molecular Weight: 540.0.
Purity: >99.5% Pure by Achiral and Chiral HPLCs.
QC: Achiral and Chiral HPLCs, MS, NMR, and Quantitative Elemental analysis Report.
Solubility: Refer to Certificate of Analysis.
Storage: Refer to Certificate of Analysis.
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