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Conditions of optimal LAMP2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
Lysosomal associated membrane protein 2 (LAMP2), also known as CD107b, is a major component of lysosomal membranes. LAMP2 is a transmembrane glycoprotein about 110 kDa. Mature human LAMP2 consists of a 347 aminoacid (aa) intralumenal domain, a 24 aa transmembrane segment, and a 35 aa cytoplasmictail. The lumenal domain is organized into twoheavily N-glycosylated regions. Alternate splicing generates a human LAMP2 isoform (LAMP2B) with a substituted juxtamembrane lumenal region, cytoplasmic tail and transmenmbrane segment. LAMP2 itself can cleavage lysosomal luminal domain and degradation lysosomal. In the help of chaperone HSC73, LAMP2 mediates the lysosomal uptake in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles.
BP001341-C483: Recombinant Human Lysosome-Associated Membrane Glycoprotein 2 (LAMP2) Protein
Source: HEK 293-derived.
Recombinant Human Lysosome-Associated Membrane Glycoprotein 2 (LAMP2) Protein is a secreted protein with sequence (Leu29-Ile375) of Human LAMP2 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other LAMP2 Proteins:
Recombinant Human LAMP2 Protein
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