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Conditions of optimal Lamin ? antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Background
Lamins are the major components of the nuclear lamina which underlies the nuclear envelope of eukaryotic cells. lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubule assembly and organization in mitosis. Inspection of the deduced amino acid sequence of lamin B revealed the presence in coil 1B of the alpha-helical domain of a leucine heptad repeat region.Lamin B assembled into a matrix-like network in mitosis through a process that depended on the presence of the guanosine triphosphate-bound form of the small guanosine triphosphatase Ran.
PA000135-PA1048: Lamin β Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: Human, rat. No cross reactivity with other proteins.
Applications: Western blot: At 0.1-0.5 ug/ml with the appropriate system to detect Lamin B in cells and tissues. Immunohistochemistry(P): At 0.5-1 ug/ml to detect Lamin B in formalin fixed and paraffin embedded tissues. Boiling the sections is required.
Reactivity: Human, Rat.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human Lamin B1, different from the related rat sequence by one amino acid, mouse sequence by three amino acids..
Purification: Immunogen affinity purified.
Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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