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Conditions of optimal KLF2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
KLF2(Krueppel-like factor 2), also known as LKLF (LUNG KRUPPEL-LIKE ZINC FINGER TRANSCRIPTION FACTOR), is a protein that in humans is encoded by the KLF2 gene. Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1) and the selectin CD62L. Kozyrev et al. (1999) mapped the KLF2 gene to chromosome 19p13.13-p13.11, close to the KLF1 gene, by radiation hybrid analysis. Wani et al. (1999) mapped the KLF2 gene to 19p13.1 by somatic cell hybrid analysis and FISH. Buckley et al. (2001) showed that expression of LKLF in a T-cell line induced reversible quiescence resulting in marked inhibition of proliferation, decreases in cell size and protein synthesis, and reduced expression of activation markers. They concluded that LKLF functions, in part, by negatively regulating a MYC-dependent pathway.
PA006731-PA1919: KLF2 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Applications: WB 0.1-0.5 ug/ml.
Reactivity: Human, Rat, Mouse.
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of mouse KLF2, identical to the related rat sequence sequence by one amino acid and different from the related human sequence by one amino acid.
Purification: Immunogen affinity purified.
Form of Antibody: Lyophilized.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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