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Conditions of optimal K-ras antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
BACKGROUND
K-ras, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, is a protein that in humans is encoded by the KRAS gene. Like other members of the Ras family, the K-ras protein is a GTPase and is an early player in many signal transduction pathways. K-ras is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. The K-ras gene spans 38 kb and contains 4 exons. By in situ hybridization, the K-ras gene is mapped to chromosome 12p12.1-p11.1. K-ras acts as a molecular on/off switch. Once it is turned on it recruits and activates proteins necessary for the propagation of growth factor and other receptors' signal, such as c-Raf and PI 3-kinase. K-ras binds to GTP in the active state and possesses an intrinsic enzymatic activity which cleaves the terminal phosphate of the nucleotide converting it to GDP.
PA004994-PA1457: K-ras Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: Human, mouse, rat. No cross reactivity with other proteins.
Applications: WB 1ug/ml.
Reactivity: Human, Mouse, Rat.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human K-ras, identical to the related mouse and rat sequences.
Purification: Immunogen affinity purified.
Form of Antibody: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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