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Conditions of optimal IFNAR1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
The Interferon-alpha/beta Receptor 1 (IFN-alpha/beta R1) is a receptor which binds Type I Interferons including Interferon-alpha and -beta. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-alpha/beta R1, in association with IFN-alpha/beta R2, is required for propagating antiviral signal transduction triggered by IFN-alpha and -beta. IFN-alpha/beta R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-alpha/beta R2. Ligands associate with IFN-alpha/beta R2, and this complex subsequently forms a stable ternary assembly with IFN-alpha/beta R1. IFN-alpha/beta R1 also associates with IFN-alpha R2 even in the absence of IFN-alpha stimulation. Human IFN-alpha/beta R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.
BP001373-C358: Recombinant Human Interferon Alpha/Beta Receptor 1 (IFNAR1) Protein
Source: HEK 293-derived.
Recombinant Human Interferon Alpha/Beta Receptor 1 (IFNAR1) Protein is expressed with sequence (Lys28-Lys436) of Human IFNAR1 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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